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INTERNET FAMILY DOCTOR

The CASE for using IVERMECTIN to treat

COVID 19 infections

IVERMECTIN inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models

Paucia Nappi, … , Gary D. Brayer, Martin Gleave

Published February 3, 2020; First published December 17, 2019
Citation Information: J Clin Invest. 2020;130(2):699-714. https://doi.org/10.1172/JCI130819.

 How this Drug Works: 1

 as studied in the LAB (in vitro)

 

.

      The diagram above found by me on 10-6-2020 on Science Direct Web Site shows where some of the drugs used to treat COVID 19 Infections work to inhibit this virus' REPLICATION and effects.

INFECTED INDIVIDUAL shown at the left.

     The pathway of the virus in the middle.  Actions  of various drugs in red type on the right.

      1. Interfering with glycolization of receptor and blocking receptor:

             Convalescent Plasma, Hydroxychloroquin and Chloroquin.

     2. Premature termination of RNA transcription:

              Remdesvir

     3. Blockage of Protein Processing.

               Lopinavir and Ritanavir

     4. Blocking Cytokine Storm.

              Anticytokine drugs like Arakinra and Antinflammatory cytokine

IN THE CENTER DIAGRAM

    COVID 19 attaches to ACE-2 receptor (1)

      ENTERS into host (double line) (2) RNA replication begins

      PROTEIN translation begins (3) Bottom arrow right - new virions made which are seen

           exiting on right-- THIS LEADS to CYTOKINE STORM.

    THE CENTER shows shedding of ACE-2 receptors.

          ADAM 17 is shown as early RESPIRATORY DISTRESS.

     The lower object with windmill like "arms" is an INFLAMMASOME- labelled here

         UNNF-KB  which adds to more RESPIRATORY DISTRESS as new virions leave

          to repeat process.

         RESEARCHERS are discovering that IVERMECTIN works at not just ONE

         but several of these sites to halt the virus almost completely in 48 hours!       

          How COVID Drugs Work: 2

A Major Effect of IVERMECTIN in humans infected with Covid 19 is the INHANCEMENT of INTERFERON ---

 Aug 27, 2020 · Ivermectin acts by inhibiting the host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process that viruses hijack to enhance infection by suppressing the host antiviral response. 3 Ivermectin is therefore a host-directed agent, which is likely the basis for its broad-spectrum activity in vitro against the viruses that cause dengue, Zika, HIV, and yellow fever. 3-6 [and now Covid 19] [my addition not that of NIH]

 this stops Covid's ability to replicate in vitro and in your body almost 100%

             NIH defends its decision to not support the use of IVERMECTIN in treating Covid 19 with the following explanation:

          "Ivermectin has been shown to inhibit the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cell cultures.7 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.8,9 Even though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) against SARS-CoV-2 in vitro.10,11

Ivermectin is not approved for the treatment of any viral infection, including SARS-CoV-2 infection. The FDA issued a warning in April 2020 that ivermectin intended for use in animals should not be used to treat COVID-19 in humans.

Clinical Data in Patients With COVID-19

The available clinical data on the use of ivermectin to treat COVID-19 are limited.

Retrospective Analysis of Using Ivermectin in Patients With COVID-19

This study has not been peer reviewed.

This retrospective analysis of consecutive patients with confirmed SARS-CoV-2 infection (27% with severe COVID-19) who were admitted to four Florida hospitals compared patients who received at least one dose of ivermectin (n = 173) to those who received "usual care" (n = 103). The primary outcome was all-cause, in-hospital mortality. The secondary outcomes included mortality in patients with severe disease (defined as "need for either FiO2 ≥50% or noninvasive or invasive mechanical ventilation") and extubation rates in those who were mechanically ventilated.12

Results

  • Ivermectin administration was reportedly consistent with hospital guidelines: a single dose of 200 µg/kg, with repeat dosing on Day 7 if the patient was still hospitalized (13 patients received a second dose). Ninety percent of the ivermectin group and 97% of the usual care group received hydroxychloroquine (the majority received hydroxychloroquine in conjunction with azithromycin).
  • All-cause mortality was lower among the patients in the ivermectin group than among patients in the usual care group (OR 0.27; P = 0.03). The mortality benefit appeared to be limited to the subgroup of patients with severe disease.
  • There was no difference between the groups for the median length of hospital stay (7 days in both groups) or the proportion of mechanically ventilated patients who were successfully extubated (36% in the ivermectin group vs. 15% in the usual care group; P = 0.07).

In carefully controlled use in actual SICK Patients with positive Covid 19 tests the results have sometimes been astounding! Even in VERY SICK patients about to be put on respirators! In India, Bangladesh, Australia, Peru, and in Broward County, Florida, USA [but not the rest of the USA].

The CDC and NIH and FDA are blocking IVERMECTIN treatment of confirmed Covid 19 Infections and Pneumonia except in trial studies.

Meanwhile they are promoting only wearing MASKS and 6 feet social distancing.

WHEN President Donald Trump was admitted to Walter Reed hospital

this very week as I am writing this he was given IV Remdesivir, a special coctail of

polyclonal ANTIBODIES (like convalescent serum), and Dexamethazone

(a steroid acting against "cytokine storm")

He was NOT given IVERMECTIN, which the CDC is choosing to ignore at the

moment in favor of much more expensive and hard-to-obtain medicines.

To be sure they could claim IVERMECTIN is "experimental" but so are

the drugs they allowed to be used on Donald Trump!

He was also taking VITAMIN D and Zinc and Pepcid.

 Vitamin D and Zinc

are in my Protocol and available to all!

In INDIA, in the large state of Uttar Pradesh, where thousands are catching Covid 19, medical authorities now MANDATE IVERMECTIN

This state's official Protocol is given HERE!

 

 

Step 6 IF UNABLE TO PREVENT COVID INFECTION

I'M SUGGESTING YOU RESORT TO

IVERMECTIN Rx

This potent anti-parasite medicine is familiar to most pet-owners and farmers who own horses and cattle, and to  the natives of AFRICA and SOUTH AMERICA who are given this medication  FREE once a year to prevent BLINDNESS caused by PARASITES.  Pregnant women and babies should not take this drug.

INVERMECTIN 12 MG for an average size human

will stop almost all Covid 19

activity in 24-48 hours!

Step 7 AVOID OR RESIST VACCINES promoted by deceptive HEALTH ADS "WAITING FOR A MIRACLE VACCINE" has not saved thousands of PEOPLE and due CAUTION may save you also.  A treatment DRUG like IVERMECTIN is your BEST now available BET!

YOU MAY NEED TO RESORT TO

IVERMECTIN Rx

This potent anti-parasite medicine is familiar to most pet-owners and farmers who own horses and cattle, and to  the natives of AFRICA and SOUTH AMERICA who are given this medication  FREE once a year to prevent BLINDNESS caused by PARASITES.  Pregnant women and babies should not take this drug.

INVERNECTIN 12 MG for an average size human

will stop almost all Covid 19

activity in 24-48 hours!

Instead of doing nothing but "Social Distancing" and "Economic Lockdown" Dr. Holt promotes the use of anti-Parasite drug Ivermectin by those infected with Covid virus.

To Continue ---